Concept

Alignment — where it appears

A pairing of two strings' characters in order, with gaps where one has no partner, which is the witness an edit distance produces beside its number. There are usually many optimal ones and a traceback returns one by a tie-break, so a drawn alignment is a convention unless the count is printed beside it.

Named by 15 essays across 5 fields — each of them below, with the objects they name alongside it.

abrocadabroabracadabra012101221012210122112222123321233212332123321233212322one unit = one subproblem given a value54 of 144 cells, 90 skipped

A band as wide as the answer

If two strings are close, the optimal route stays near the diagonal and nine cells in ten cannot be on it. A band of three finds the right answer on a pair 300 characters long — and a band of thirty-two is needed before anything can prove it.

tables · Distance
acgtacgtseen ->0313303113033130a gap of k characters costs 2krows: expected · columns: seen · unit: bitslinear gaps

A cost that is not one

The same eighty-one cells, filled by the same recurrence, return 6, 10, 10 and 15 — in edits, in cost, in bits and in bits again. Only the first is a count of anything, two of them are equal by arithmetic coincidence, and the alignment each one chooses is different.

tables · Cost
0%25%50%75%100%11.522.533.545what a matching character is worthreported as the shared region, of the longer sequencea random pair scores zero hereunit cost, alphabet acgtthe region found: 13 characters at the left, 34 at the right

The zero that moves the answer out of the corner

One extra term in the recurrence — a floor at zero — and the answer stops being in the last cell. It becomes a maximum over all 1,040 of them, the traceback's starting point is a search, and the whole mode is meaningless unless a randomly matched pair of characters scores negative on average. That last condition is on the scoring scheme, not on the sequences.

tables · Cost
agcacacggatcagccagggagta09101112131415161718192021229110101212141416171819192122101021011121314151718191920221110113101212141516171920192112121012411131314151718202119131312111351214131416181921211414131312146131413151719202115141514131314714151316181921161614161514141571416141719191717171517161515168151615182018171818151816161617816171519one unit = one subproblem given a value495 cells across three tables, 980 transitions

A cell that has to know where it is

A gap of four characters is usually one event, not four. No recurrence over a single table can charge it that way, because the price of a gap character depends on how the cell above it was reached and a cell holding one number has thrown that away. The repair is three tables, and it costs exactly three times the cells.

tables · Cost
cost per column of the alignmentab / ba1.00 over 2 · 0.67 over 3kitten / sitting0.43 over 7 · 0.43 over 7intention / execution0.56 over 9 · 0.50 over 10gattaca / gactata0.29 over 7 · 0.29 over 7abracadabra / abrocadabro0.18 over 11 · 0.18 over 11unit cost, in edits per columnupper bar: the optimum, divided · lower bar: the best rate

A distance divided by a length is not a rate

Two substitutions turn "ab" into "ba", a distance of two over an alignment of two columns — a rate of 1.00. Deleting, matching and inserting also costs two, over three columns, for 0.67. Both are alignments of the same pair, the second has the better rate, and the optimal alignment is not the one that achieves it. Over every pair of strings up to three characters on three letters, 21% disagree.

tables · Cost
gactacgatgattacagt0123456789101234567821012345673211123456432212345554332123456543321234765443222387655432339876554333one unit = one subproblem given a value100 cells, 100 held at once

A distance that is a path through a grid

How far apart two strings are is a shortest-path problem on a grid whose every edge is drawn by the recurrence — and finding a string in a text costs 4,988 character comparisons where measuring how far it is from one costs 96,000.

text · Distance
executionintention0123456789112345667822234567773333455678434345667854444567776555555678766666656787777776569888888765one unit = one subproblem given a value110 cells for one divide step, 30 held

The alignment that fits in one line

Compute the table twice and hold three rows of it. The factor of two is a geometric series and is predicted exactly; measured, it comes down from 2.269 to 2.052 as the strings grow, and the peak is 3(m+1) cells on the nose.

space · Distance
stay 0.9, 400 pairsacgtacgt0525505225045240stay 0.5, 400 pairsacgtacgt0212202112022120cost of aligning the row letter with the column letterpseudocount 1

The matrix a corpus wrote

A substitution matrix is not a property of an alphabet. Fit one to four hundred pairs of sequences that rarely change and the dearest substitution costs five; fit the same model to four hundred pairs that often change and it costs two. Two hundred test pairs aligned under each matrix give different alignments in 115 cases — and a matrix fitted to eight pairs of the first kind moves 79 of them, from sampling alone.

tables · Cost
ttacgggacgtaccagtacgt000000000000000000111011110111011011222101221012101112333210122101211212433321123210122221one unit = one subproblem given a value90 cells, top row zero, answer read from the last row

The row that starts at zero

The same 1,413 cells, filled by the same recurrence in the same order, answer 148 and 0. One line of initialisation decides which question the table was asked, and only one of the two answers is about whether the pattern is there.

text · Distance
123456123456cost to open a gapcost to extend a gapintentionexecution571 settingsinte---ntion---execution3 settingsinte-ntion-execution1 setting-intentionexec-ution1 settingintention against execution, affine costseach colour is one optimal alignment

The parameter plane has few answers

Sweep the cost of opening a gap against the cost of extending one over five hundred and seventy-six settings, and the optimal alignment of intention against execution takes four values — one of them at 571 of the settings. Under a linear model the plane divides into three wedges through the origin, because doubling every cost changes nothing and only the ratio is a parameter. Tuning an aligner is choosing a region, and most of the plane is one.

tables · Cost
rounded to whole bitsunroundeda resample, 400 near pairs0.860.9340 pairs at stay 0.90.820.928 pairs at stay 0.90.710.88400 pairs at stay 0.70.680.86400 pairs at stay 0.50.620.790.5: no prediction200 test pairs, 16 directionsdashed: a coin flip

The ties a rounded matrix makes

Measure how far each optimal alignment is from a tie — the smallest change to any one cost that makes another alignment win — and it predicts which alignments a refitted substitution matrix will move. A resample of the same corpus moves 30 of the 63 test alignments that sit on a tie and 3 of the other 137. A matrix fitted to a different divergence moves alignments far from a tie as well, and the prediction weakens to a chance of 0.62. And a third of the alignments were on a tie only because the matrix was rounded to whole bits — fitted without rounding, 15 of 200 are, and every prediction improves.

tables · Cost
alignments on a tiedistinct costs · predictionwhole bits633 of 6 · 0.86half bits793 of 6 · 0.91quarter bits414 of 6 · 0.93a grain of 0.2235 of 6 · 0.89eighth bits156 of 6 · 0.93a grain of 0.05205 of 6 · 0.95unrounded156 of 6 · 0.93200 test pairs, 16 directionsbar: alignments within 0.01 of a tie

The lattice that decides the ties

Rounding a fitted substitution matrix to whole bits puts 63 of 200 alignments on a tie where the exact fit puts 15. Rounding to half bits — a finer grain, and the obvious repair — puts 79. What tracks the ties is not how fine the lattice is but how many of the six fitted costs it keeps apart: whole and half bits both leave three, an eighth of a bit leaves all six, and matches the exact fit exactly.

tables · Cost
unit cost — triples broken0.02%unit cost — pivot bound failed0.02%log-odds on a keyboard walk — triples broken6.61%log-odds on a keyboard walk — pivot bound failed13.22%42,840 triples per model, enumerated0.02% shown where the true rate is zero

A distance that is not a distance

Under unit cost the edit distance obeys the triangle inequality and this site asserts that it does. Under a stated substitution matrix it need not, and on 42,840 enumerated triples it fails 2,832 times — taking with it every structure that prunes by distance, at a measured 13.22% of the bounds they rely on.

wrong · Cost
48163264128110entry width, bytescache lines a lookup readsentries inlinea line of tags in front8,192 slots, load 0.9, buckets of 8keys the table holds

A lookup that stops caring how wide an entry is

Buckets of eight entries aligned to a cache line read 1.20 lines a lookup when an entry is eight bytes and 19.25 when it is 128, because the bound was arithmetic about alignment and the arithmetic stops holding. Keeping one byte of each key's hash in a separate array and the entries in a parallel one reads 2.21 lines at every width from four bytes to sixty-four — and for a key the table does not hold, 2.05 against 31.98.

machine · Machine
124816326410step width, cellscache lines a stepstored by diagonalsby diagonals, each line-alignedstored by rows512 × 512, lines of 8 cellsone step of an anti-diagonal

Eight cells at once

The anti-diagonal fill order exists because its cells do not depend on one another, and every table filled here has been walked one cell at a time anyway. Computed eight at a time, a step touches 5.71 cache lines on the layout that stores the table by diagonals and 10.87 on the one that stores it by rows — and per cell the first keeps falling to 0.42 while the second stops at 1.27. The prediction that a diagonal step would touch three or four lines was wrong, and line-aligning each diagonal only takes it to 4.94.

machine · Machine

Named alongside it

The objects these essays reach for when they reach for this one.

Cost modelEdit distanceDynamic programmingHonest limitSubproblemSubstitution matrixTracebackMeasurementParameter choiceTrade offAffine gapApproximate matching

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