Concept

Sensitivity analysis — where it appears

The measurement of how much an answer changes when the numbers it was computed from change. For an optimisation it asks how far the inputs can move before a different answer becomes best, which says how much of the reported answer the data supports.

Named by 3 essays across one field — each of them below, with the objects they name alongside it.

123456123456cost to open a gapcost to extend a gapintentionexecution571 settingsinte---ntion---execution3 settingsinte-ntion-execution1 setting-intentionexec-ution1 settingintention against execution, affine costseach colour is one optimal alignment

The parameter plane has few answers

Sweep the cost of opening a gap against the cost of extending one over five hundred and seventy-six settings, and the optimal alignment of intention against execution takes four values — one of them at 571 of the settings. Under a linear model the plane divides into three wedges through the origin, because doubling every cost changes nothing and only the ratio is a parameter. Tuning an aligner is choosing a region, and most of the plane is one.

tables · Cost
rounded to whole bitsunroundeda resample, 400 near pairs0.860.9340 pairs at stay 0.90.820.928 pairs at stay 0.90.710.88400 pairs at stay 0.70.680.86400 pairs at stay 0.50.620.790.5: no prediction200 test pairs, 16 directionsdashed: a coin flip

The ties a rounded matrix makes

Measure how far each optimal alignment is from a tie — the smallest change to any one cost that makes another alignment win — and it predicts which alignments a refitted substitution matrix will move. A resample of the same corpus moves 30 of the 63 test alignments that sit on a tie and 3 of the other 137. A matrix fitted to a different divergence moves alignments far from a tie as well, and the prediction weakens to a chance of 0.62. And a third of the alignments were on a tie only because the matrix was rounded to whole bits — fitted without rounding, 15 of 200 are, and every prediction improves.

tables · Cost
alignments on a tiedistinct costs · predictionwhole bits633 of 6 · 0.86half bits793 of 6 · 0.91quarter bits414 of 6 · 0.93a grain of 0.2235 of 6 · 0.89eighth bits156 of 6 · 0.93a grain of 0.05205 of 6 · 0.95unrounded156 of 6 · 0.93200 test pairs, 16 directionsbar: alignments within 0.01 of a tie

The lattice that decides the ties

Rounding a fitted substitution matrix to whole bits puts 63 of 200 alignments on a tie where the exact fit puts 15. Rounding to half bits — a finer grain, and the obvious repair — puts 79. What tracks the ties is not how fine the lattice is but how many of the six fitted costs it keeps apart: whole and half bits both leave three, an eighth of a bit leaves all six, and matches the exact fit exactly.

tables · Cost

Named alongside it

The objects these essays reach for when they reach for this one.

AlignmentCost modelOptimalityParameter choiceCorpusEstimatorFittingHonest limitRoundingSubstitution matrixTracebackAffine gap

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